Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Hungary
Thursday 13 July 2006, 16:00
Seminar Room B10 (Basement)
Alexandra House, 17 Queen Square, London, WC1N 3AR
Inputs from different sources are processed in distinct ways in
hippocampal neurons and networks
Cortical areas receive afferent input from multiple sources, which often innervate distinct domains of the dendritic tree of pyramidal cells, and may subserve different computational functions. This hypothesis was first investigated in morphologically and biophysically detailed models of single hippocampal pyramidal neurons. Simulations revealed dramatic differences between the two main input pathways in terms of their efficacy, rules of summation, and interactions with intracellular events such as dendritic action potentials. The consequences of such differences were then explored in a model of the hippocampal network which also included some of the major classes of inhibitory interneuron. We found that the two pathways contributed rather differently to spiking activity in the pyramidal cell population, and also played distinct roles in hippocampal network oscillations. Finally, I will also discuss the methods I developed for the systematic simplification of detailed compartmental neuronal models.