
Carl van Vreeswijk
Paris University, France
Wednesday 5 April 2006
16:00
Seminar Room B10 (Basement)
Alexandra House, 17 Queen Square, London, WC1N 3AR
Does dendritic shunting inhibition change the neuronal gain?
I present a simple model of a spatially extended spiking neuron which can be studied analytically. The model consists of a soma, modeled as an integrate and fire neuron, coupled to a passive dendritic cable. I show how this model can be analyzed. The basic properties of the modelare presented and I determine how shunting inhibition at different locations affect the transfer function of the neuron. Somatic shunting inhibition shifts the transfer function to the right, reminiscent to the results for single compartment models. Dendritic shunting inhibition has a weak subtractive effect for inputs that arrive at the soma. For dendritic excitatory inputs the results depend on the distribution of the excitatory and inhibitory inputs. There are configurations in whichshunting inhibition shifts the transfer function to the right, ones for which the transfer function is shifted downward, ones which have a multiplicative effect on the gain for a given input level and also ones which multiply the gain at a given firing rate.