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An 'all-optical' approach for probing network dynamics in vivo
Michael Hausser
University College London

Neural circuits display complex spatiotemporal patterns of activity on the millisecond timescale during behavior. Understanding how these activity patterns drive behavior is a fundamental problem in neuroscience, and remains a major challenge due to the complexity of their spatiotemporal dynamics. I will describe a strategy for "all-optical" simultaneous imaging and manipulation of patterns of activity in neural circuits in vivo with single-spike and single-neuron precision. This approach should open up new experiments for probing the nature of the neural code during behaviour.

[1] Packer et al. Nature Methods 12: 140-6 (2015).