The discovery of topographic organization of spatial encoding by neurons in layer II of the medial entorhinal cortex (MEC) provides an opportunity for systematic investigation of cellular mechanisms important for computation in cognitive circuits. We recently found that the way neurons in layer II of the MEC respond to synaptic input follows a similar topographical organization to the resolution of spatial firing fields in behaving animals. This talk will address the mechanisms that organize synaptic responses of layer II neurons and the implications of synaptic response tuning for models that explain generation of grid firing fields.
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