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A burst-timing based learning rule at the retinogeniculate synapse
Daniel A. Butts, Patrick O. Kanold, Carla J. Shatz
Harvard
Synaptic refinement in the mammalian lateral geniculate nucleus (LGN)
requires neural activity. Learning rules that specify how
combinations of pre- and postsynaptic activity lead to changes in
synaptic efficacy are thought to underlie this activity-dependent
development, though it is unclear how natural activity patterns drive
such refinement. We address this question using an integrated
experimental and theoretical approach. First, we determined what
aspects of the spontaneous activity in the retina present during this
development carry information that could instruct refinement, leading
to the prediction of a learning rule based on the timing between
presynaptic and postsynaptic bursts. Then, using perforated patch
recording in slice preparations of early postnatal rat LGN, we
recorded from LGN neurons and measured the size of postsynaptic
currents evoked by optic tract stimulation, both before and after a
burst-time-based stimulation paradigm. We found that the magnitude
and direction of synaptic plasticity depends on the latency between
pre- and postsynaptic bursts, suggesting how a "burst-time dependent"
learning rule could use natural activity patterns to drive synaptic
refinement. We then use simple simulations of the retinogeniculate
system to demonstrate how the observed rules of synaptic plasticity
observed in vitro at the single synapse can explain the system-level
activity-dependent development observed in vivo.