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Decoding memory of sequential experience in the hippocampus during
slow wave sleep
Albert K. Lee and Matthew A. Wilson
MIT
Rats repeatedly ran through a sequence of spatial receptive fields of
hippocampal CA1 place cells in a fixed temporal order. A novel
combinatorial decoding method reveals that these neurons repeatedly
fired in precisely this order in long sequences involving 4 or more
cells during slow wave sleep (SWS) immediately following, but not
preceding, the experience. The SWS sequences occurred intermittently
in brief (~100-millisecond) bursts, each compressing the behavioral
sequence in time by approximately 20-fold. This rapid encoding of
sequential experience is consistent with evidence that the hippocampus
is crucial for spatial learning in rodents and the formation of long
term memories of events in time in humans.