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Energetic costs and speed limits in neocortical axons
Samuel S.-H. Wang, Kimberly H. Harrison, Jennifer R. Shultz, Mark J.
Burish, and Matthew W. Wagers
Princeton University
In large brains, action potentials must travel for long distances,
potentially increasing the time taken for information processing. This
scaling problem is particularly apparent in mammalian brains, which
vary in diameter by nearly 100-fold. Here we present evidence for
adaptations for speed and energetic efficiency in long-distance axons
of the neocortex. Axonal propagation speed can be increased by making
axons wider and by adding myelin sheaths. We find that across
species, the mean axon diameter and the degree of myelination increase
steeply with brain size, indicating that conduction is faster in
larger brains. The largest axons are proportional in width to brain
diameter, suggesting that minimum cross-brain conduction time is
conserved among mammals. Myelination also reduces the energetic cost
of generating action potentials. As a result, the estimated
per-volume cost of spike activity scales as the -0.30±0.09 power of
body size, consistent with previously observed scaling of metabolic
rates. Increases in axon size also account for the disproportionate
growth in white matter volume, which for large brains can occupy
nearly half the neocortex. Brain tissue is energetically expensive,
and thus improvements in processing speed may be limited by the
metabolic costs of an expanding white matter architecture.