Instructive signals in the cerebellum during motor learning

Jennifer Raymond


Learning requires that changes occur at appropriate sites in the relevant neural circuits. What are the neural events that trigger such changes? Which neurons carry the instructive signals that control the induction of plasticity in vivo? We are using a simple motor learning task as an experimental system for exploring these questions in the cerebellar circuitry. The answers are critical for understanding how the synaptic plasticity mechanisms that have been described in vitro operate in the functional context of the intact brain.