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Temporal precision in coincidence detecting auditory neurons
John Rinzel, G. Svirskis, V. Kotak, and D. Sanes
NYU
Localization of low frequency sounds involves precise computation of
interaural time differences (sub-ms range). The first neurons that
receive binaural input and participate in this computation are, for
mammals, in the medial superior olive (MSO) and they have distinct
biophysical properties. They spike in response to transient but not to
slowly varying stimuli and phase-lock well to periodic input. A
low-threshold potassium current IK-lt contributes to the MSO
neuron's temporal processing qualities partly because the membrane's
"time constant" is shortened by this extra conductance but the dynamic
aspects of IK-lt activation also play a role. Transient
signals must outrace the activation of IK-lt if they are to
cause the cell to spike. We characterize the role of IK-lt
through in vitro experiments (gerbil MSO) and with computational
models, of the Hodgkin-Huxley and enhanced integrate-and-fire types.
We focus particularly on what makes these coincidence-detecting cells
fire, i.e. on how they integrate subthreshold signals in the presence
of a noisy synaptic background, typical of the peripheral auditory
system. Our results show that partial block of IK-lt
reduces: (1) the signal-to-noise ratio, (2) the probability to fire in
response to closely-timed inputs, (3) the quality (vector strength) of
phase-locking, and (4) the temporal sharpness of transient currents
that cause spiking (as seen with reverse correlation analysis).